Can a PCOS Supplement Support Aspects of Male Reproductive Health? An Evidence-Based Review

WrenLife’s Hormone Health supplement was formulated to support women’s hormonal and metabolic balance. However, its nutrient blend raises an interesting question: could some of these same ingredients also have relevance for certain aspects of male reproductive wellness?

Hormone Health contains:

• Myo-Inositol – 2000 mg

• D-Chiro-Inositol – 50 mg

• Vitamin D₃ – 2000 IU

• Magnesium (as glycinate) – 200 mg

• Zinc (as citrate) – 15 mg

• Chromium (as picolinate) – 200 μg

• Vitamin K₂ (as MK-7) – 90 μg

• Alpha-Lactalbumin – 50 mg

Several of these nutrients have been studied for potential roles in sperm function, hormone balance, and oxidative stress modulation. Below is a review of the peer-reviewed evidence — this is for educational purposes only and does not claim that Hormone Health is intended for men or proven to treat, cure, or prevent any disease.

---

Ingredient Evidence Overview

Myo-Inositol (2000 mg)

A 2024 systematic review and meta-analysis found myo-inositol supplementation in men with fertility concerns was associated with improved sperm motility, testosterone levels, and DNA integrity. Some studies also reported higher pregnancy rates in assisted reproduction contexts¹. These effects are thought to be linked to myo-inositol’s role in mitochondrial energy production in sperm cells.

D-Chiro-Inositol (50 mg)

Evidence is more limited. One small human pilot study suggested potential effects on testosterone and androgen regulation², while in vitro studies reported benefits for sperm mitochondrial function and motility³. Larger, well-controlled human trials are needed.

Vitamin D₃ (2000 IU)

Randomized controlled trials in vitamin D-deficient men have linked supplementation to improvements in sperm motility and morphology⁴. Effects appear strongest when correcting deficiency rather than supplementing in men with adequate baseline vitamin D status.

Magnesium (200 mg as Glycinate)

Magnesium contributes to cellular functions that affect sperm structure and movement. Some observational studies note lower seminal magnesium levels in men with reduced fertility⁵, though supplementation trials show mixed outcomes⁶. Benefits may be more likely in those with suboptimal magnesium status.

Zinc (15 mg as Citrate)

Zinc is crucial for sperm formation, motility, and hormone metabolism. Meta-analyses in zinc-deficient men have linked supplementation to improved semen volume, motility, and morphology⁷. Results in men with adequate zinc status are less consistent⁸.

Chromium (200 μg as Picolinate)

Most evidence comes from animal models, showing chromium picolinate may improve sperm quality and reduce oxidative stress in diabetic conditions⁹. No high-quality human fertility studies are currently available.

Vitamin K₂ (MK-7, 90 μg)

Animal studies suggest vitamin K₂ may influence testosterone synthesis¹⁰. No direct human trials have evaluated its impact on male reproductive outcomes.

Alpha-Lactalbumin (50 mg)

While not directly studied for male reproductive health, alpha-lactalbumin — a whey protein fraction — can enhance nutrient absorption, including inositols¹¹. This could indirectly support the action of other nutrients in the formula.

---

Summary

Some ingredients in Hormone Health — particularly myo-inositol, vitamin D₃, and zinc — have been studied for possible roles in supporting aspects of male reproductive health, especially where deficiencies are present. Others, such as D-chiro-inositol, chromium, vitamin K₂, and alpha-lactalbumin, have more preliminary or indirect evidence.

This information is educational and not a recommendation for men to use Hormone Health. Anyone considering supplements for reproductive wellness should consult a qualified healthcare provider.

---

Disclaimer: This article is for educational purposes only and is not a substitute for medical advice. Always seek the guidance of a qualified healthcare provider before starting any supplement. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

---

References

1. Ghaemi, M., et al. Food Science & Nutrition, 2024.

2. Nordio, M., et al. Basic and Clinical Andrology, 2021.

3. Condorelli, R.A., et al. Journal of Clinical Medicine, 2020.

4. Maghsoumi-Norouzabad, L., et al. Reproductive Biology and Endocrinology, 2021.

5. Abdul-Rasheed, O.F., et al. Oman Medical Journal, 2010.

6. Závaczki, Z., et al. Magnesium Research, 2003.

7. Zhao, J., et al. Scientific Reports, 2016.

8. Schisterman, E.F., et al. JAMA, 2020.

9. Zheng, H., et al. Molecules, 2023.

10. Ito, A., et al. Lipids in Health and Disease, 2011.

11. Kamenov, Z., et al. Metabolites, 2023.