Updated October 5, 2026.
Hormone Health includes vitamin D3 and vitamin K2 because both have roles in normal calcium and bone metabolism. Researchers have also investigated broader metabolic and reproductive questions. We keep those findings in context: ingredient research does not establish that this finished formula treats PCOS or prevents calcium buildup in blood vessels.
Vitamin D3: calcium, bone, and immune support
Vitamin D supports intestinal calcium absorption, normal bone mineralization, and immune function. Its biology also involves cell signaling.1 Those nutrient roles support including vitamin D without promising that it will correct a hormone imbalance.
Vitamin D has been studied in women with PCOS, including people with low vitamin D levels. Some trials report improvements in selected hormone or cycle measurements. For example, a 2025 trial evaluated 30,000 IU weekly using placebo-controlled and open-label phases and reported favorable findings for some outcomes.3 That regimen and study population differ from Hormone Health. It does not establish a benefit for every person, for this product, or for adding K2.
Vitamin K2: normal bone metabolism and vascular research
Vitamin K helps activate proteins involved in blood clotting and bone metabolism, including osteocalcin. Matrix Gla protein is another vitamin K-dependent protein studied in relation to vascular calcification.2 These mechanisms do not prove that a supplement directs calcium away from arteries or kidneys.
There is human research worth retaining. A three-year placebo-controlled trial in 244 postmenopausal women found improvements in some arterial-stiffness measures with 180 mcg of MK-7 daily.4 This was a different population and twice the MK-7 amount in Hormone Health; the findings are not proof of cardiovascular or reproductive benefits from this formula.
Other findings are less encouraging. A two-year randomized trial in 365 older men found that 720 mcg MK-7 plus 25 mcg vitamin D daily did not significantly slow aortic-valve calcification.5 It is therefore too strong to promise that D3 and K2 prevent or reverse calcium buildup.
Do D3 and K2 work better together?
Their biological roles are complementary, and combined supplementation remains an active research topic. A 2026 analysis of a vitamin D trial found that baseline vitamin K status did not significantly change the effects on the measured bone or cardiovascular markers. It was not a direct trial of adding K2, so it does not settle every question about the combination.6
We have not established that the D3/K2 combination in Hormone Health produces superior hormone, cycle, cardiovascular, or reproductive outcomes. The supported rationale is nutrient provision, with broader potential benefits still being investigated.
What Hormone Health provides
- Vitamin D3: 50 mcg (2,000 IU) per stick pack.
- Vitamin K2 as MK-7: 90 mcg per stick pack.
Follow the labeled serving size. Consider your total intake from other supplements and discuss individual needs with a qualified healthcare professional. Do not use during pregnancy or breastfeeding, or with a milk-protein allergy. Vitamin K can interact with warfarin and similar anticoagulants; ask your prescriber before starting or stopping this formula.2
See the full formula and safety FAQs.
Scientific references
- NIH Office of Dietary Supplements. Vitamin D fact sheet.
- NIH Office of Dietary Supplements. Vitamin K fact sheet.
- Tóth BE, et al. Vitamin D3 trial in PCOS. Nutrients. 2025;17:1246.
- Knapen MHJ, et al. MK-7 and arterial stiffness trial. Thrombosis and Haemostasis. 2015;113:1135–1144.
- Diederichsen ACP, et al. K2/D and aortic-valve calcification trial. Circulation. 2022;145:1387–1397.
- Vitamin K status and response to vitamin D: exploratory analysis. Frontiers in Nutrition. 2026;1857443.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This article is educational and does not replace individual medical advice.
