Why Vitamin D3 + K2 Matter for PCOS—And Why We Include Both in Hormone Health

At WrenLife, we take a science-backed, whole-body approach to PCOS support. That’s why our Hormone Health formula includes a combination of vitamin D3 and vitamin K2—a powerful nutrient duo that does more than support bone health. It helps your body manage calcium, inflammation, hormone balance, and metabolic function—which are all commonly impacted in women with PCOS.

Here’s why this combination matters, and how it sets our supplement apart.

☀️ Vitamin D3: The Foundation for Calcium Absorption & Hormone Health

Vitamin D3 (cholecalciferol) is often low in women with PCOS¹. It plays several essential roles:

• Supports immune health and endocrine (hormonal) function

• Aids calcium absorption in the gut

• May support insulin sensitivity and androgen balance in PCOS¹ ²

But calcium absorption is only the first step—your body still needs to manage where that calcium goes.

🦴 Vitamin K2: Guiding Calcium to the Right Places

Vitamin K2 (especially the MK-7 form) activates proteins that direct calcium into bones and teeth—and away from soft tissues like arteries and kidneys³. It supports:

• Bone mineralization

• Vascular health by reducing calcium buildup in arterial walls³

• Calcium metabolism, a process linked to both cardiovascular and endocrine function

Without enough vitamin K2, calcium can end up in places it doesn’t belong—even if you're getting plenty of vitamin D.

🔄 The Synergy: Why K2 + D3 Work Better Together

Vitamin D helps your body absorb calcium.
Vitamin K2 helps your body use calcium correctly.

Together, they:

• Support healthy bones and teeth

• Promote vascular flexibility

• Contribute to calcium balance, which is relevant for women managing PCOS symptoms like chronic inflammation, insulin resistance, and hormonal dysregulation⁴

This is why WrenLife's Hormone Health includes both—because nutrient synergy is key to long-term wellness.

🌸 PCOS & Calcium Metabolism: What’s the Connection?

Women with PCOS often experience:

• Chronic low-grade inflammation

• Insulin resistance

• Altered calcium and vitamin D signaling⁵

Emerging evidence suggests that poor calcium regulation—driven by low vitamin D status—may play a role in PCOS symptoms, including irregular cycles and androgen excess⁵ ⁶. By supporting optimal calcium utilization with vitamin K2 + D3, we aim to promote balance—not just symptom suppression.

✅ What Makes WrenLife Different?

Unlike many other PCOS supplements, WrenLife Hormone Health includes:

• 2,000 IU of Vitamin D3 – to support immune health, hormone signaling, and calcium absorption

• 90 mcg of Vitamin K2 (MK-7) – to help direct calcium to bones and away from arteries, supporting both cardiovascular and reproductive health

We include both because smart, synergistic supplementation matters.

🧬 Scientific References

¹ Pal L, Kalantaridou SN. "Vitamin D in reproductive health and polycystic ovary syndrome (PCOS)." Fertil Steril. 2010.
² Krul-Poel YHM, et al. "Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS)." Eur J Endocrinol. 2013.
³ Brandenburg VM, Reinhold D. "Vitamin K2: Role in calcium metabolism and vascular health." Thromb Haemost. 2017.
⁴ Kanellakis S, et al. "Vitamin K2 combined with D3 supplementation and bone metabolism." Nutrients. 2020.
⁵ Irani M, Merhi Z. "Role of vitamin D in ovarian physiology and PCOS." Reprod Biol Endocrinol. 2014.
⁶ Thomson RL, et al. "Vitamin D and calcium supplementation and insulin sensitivity in PCOS." Diabetes Care. 2011.

📝 Final Thoughts

You shouldn’t have to choose between hormone support and long-term wellness. With WrenLife Hormone Health, you get both—because we believe smart nutrition supports not just symptom relief, but whole-body resilience.

Disclaimer:
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.