What is WrenLife GLP-1 Support Multi+?

WrenLife’s GLP-1 Support Multi+ is a high-potency daily multivitamin formulated to address the unique needs of women with PCOS who are using GLP-1 medications.

It combines:

• Essential vitamins and minerals to help fill dietary gaps

• Specialized ingredients like MSM (methylsulfonylmethane), hyaluronic acid, and Ginfort® ginger extract

• Supportive dosages such as 3,000 µg of biotin and 25 µg of methylcobalamin (B12)

Together, these nutrients support metabolism, hormone balance, digestive comfort, and skin/hair health while helping maintain nutrient sufficiency during weight loss.

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1. Supporting Metabolic Health & Insulin Function

Women with PCOS often face challenges with insulin resistance and metabolic health. This formula includes several nutrients that help support healthy blood sugar metabolism and insulin sensitivity:

• B-Vitamins (B12, Folate, B6, Biotin) – Help convert carbohydrates, fats, and proteins into usable energy. Vitamin B12 (as methylcobalamin) is important for energy production and nerve health. Reduced appetite or slower stomach emptying from GLP-1 therapy may affect B12 intake³. Biotin (3,000 µg) supports carbohydrate metabolism and also contributes to healthy hair, skin, and nails⁹.

• Chromium – Supports healthy insulin signaling. Some studies suggest it may help maintain balanced blood sugar and healthy androgen levels in women with PCOS⁷.

• Magnesium – Important for insulin receptor activity and metabolic health⁴.

• Vitamin D3 – Deficiency is common in PCOS⁴. Vitamin D supports insulin function, menstrual cycle regularity, and bone health²¹⁰.

Takeaway: These nutrients work together to help your body use insulin effectively and maintain steady energy during weight loss.

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2. Supporting a Healthy Inflammatory Response & Antioxidant Defenses

PCOS is often associated with a chronic, low-grade inflammatory state⁵. Rapid weight loss can also temporarily increase oxidative stress. The Multi+ includes ingredients to help support a balanced inflammatory response:

• MSM (Methylsulfonylmethane) – Provides bioavailable sulfur and supports antioxidant defenses by helping maintain healthy glutathione levels⁸. May also support joint comfort and skin integrity.

• Antioxidant Vitamins (C & E) plus Zinc & Selenium – Help neutralize oxidative stress and support skin, immune, and hormone health.

• Hyaluronic Acid – Supports joint lubrication, skin hydration, and tissue resilience.

Takeaway: These nutrients help your body maintain a healthy response to inflammation and oxidative stress — supporting comfort, skin, and metabolic balance.

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3. Supporting Hormonal Balance & Reproductive Health

Balanced hormones are essential for menstrual regularity and fertility. This formula includes nutrients that may help support hormone-related pathways:

• B-Vitamins (B6, Folate, B12) – Support methylation, a process important for hormone metabolism and balanced estrogen/progesterone ratios.

• Vitamin D3 – Linked to healthy ovulation, progesterone production, and lower androgen levels in women with PCOS¹⁰.

• Zinc & Selenium – Support thyroid function and may help maintain healthy androgen activity.

• Ginfort® Ginger Extract – Traditionally used for digestive health, but research suggests it may also support healthy LH (luteinizing hormone) levels in women with PCOS¹².

Takeaway: These nutrients provide the foundation for a more balanced hormonal environment, supporting cycle regularity and reproductive wellness.

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4. Supporting Digestive Comfort During GLP-1 Therapy

GLP-1 medications can cause nausea, bloating, and slower digestion². The Multi+ includes ingredients to help make GLP-1 therapy more comfortable:

• Ginfort® High-Potency Ginger Extract – Standardized to 26% gingerols for concentrated digestive support. Research suggests ginger can help ease nausea, bloating, and discomfort⁸.

• Probiotic/Fiber Support (if used alongside) – Helps maintain regularity and gut balance during reduced food intake.

Takeaway: Supporting digestive comfort can make it easier to stay consistent with GLP-1 therapy and meet your nutrition goals.

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5. Filling Nutritional Gaps & Supporting Hair, Skin, and Bone Health

Reduced appetite during GLP-1 therapy can lead to nutrient shortfalls³. This formula helps cover:

• Vitamin B12 (25 µg methylcobalamin) – Supports red blood cell formation, nerve health, and energy metabolism⁶.

• Iron – Supports healthy oxygen transport and prevents fatigue related to low iron levels.

• Calcium + Vitamin K2 – Support bone strength, especially during rapid weight loss⁶.

• Biotin + MSM + Hyaluronic Acid + Zinc – Support hair strength, skin hydration, and nail integrity⁸⁹.

Takeaway: While you focus on your weight and health goals, this formula helps keep hair, skin, nails, and bones supported.

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Conclusion & Disclaimer

WrenLife GLP-1 Support Multi+ is designed to provide science-backed, targeted nutrient support for women with PCOS who are using GLP-1 therapy. It helps bridge potential nutrient gaps, supports key metabolic and hormonal pathways, and includes ingredients to help maintain digestive comfort.

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult your healthcare provider before starting any new supplement.

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References

1. Aboeldalyl S. et al. Chronic inflammation in PCOS. Int J Mol Sci. 2021.

2. Qie F. et al. GLP-1 receptor agonists in PCOS. BMC Endocr Disord. 2023.

3. Cassata C. Common nutrient deficiencies on GLP-1 medications. Healthline. 2024.

4. Lin MW, Wu MH. Vitamin D deficiency in PCOS. Indian J Med Res. 2015.

5. Escobar-Morreale HF. PCOS, obesity, and inflammation. Trends Endocrinol Metab. 2018.

6. Hanks J. Nutrient priorities for GLP-1 patients. MDedge Diabetes. 2024.

7. Fazelian S. et al. Chromium supplementation in PCOS. J Trace Elem Med Biol. 2017.

8. Pak OJ. et al. MSM benefits & safety. Nutrients. 2018.

9. Patel DP. et al. Biotin and hair/nail health. Skin Appendage Disord. 2017.

10. Yang M. et al. Vitamin D and fertility in PCOS. Front Endocrinol. 2023.

11. Unfer V. et al. Myo-inositol for insulin resistance in PCOS. Int J Endocrinol. 2016.

12. Jamilian M. et al. Ginger and hormone balance in PCOS. Eur J Clin Invest. 2016.