You may know hyaluronic acid from your skincare routine. It also appears in oral supplements, including WrenLife GLP-1 Support Multi+. That raises a useful question: what does taking hyaluronic acid have to do with skin hydration?
Human studies suggest that oral hyaluronic acid can help support skin hydration.* Here is what the ingredient research shows, what it does not establish, and why hyaluronic acid is included in Multi+.2,3
What is hyaluronic acid?
Hyaluronic acid, also called hyaluronan or HA, is a substance naturally present in skin and other tissues. Its ability to bind water contributes to tissue hydration. Sodium hyaluronate is the sodium-salt form used in Multi+.1
The fact that HA occurs naturally in skin is useful background. To understand an oral supplement, we also need studies that measure what happens after people take it. Results from a topical serum cannot simply be transferred to a tablet.
What does the oral-supplement research show?
A 2022 systematic review pooled four randomized trials involving 196 adults. Oral hyaluronan produced a modest improvement in measured skin hydration versus placebo (standardized mean difference 0.40; 95% confidence interval 0.11–0.68). This statistical measure is not a percentage improvement. Three trials used 120 mg daily; one used 200 mg. Follow-up lasted four to twelve weeks, with limitations in study reporting and risk-of-bias assessment.2
A later twelve-week trial randomized 150 healthy adults aged 18–60 to a daily liquid containing 60 mg or 120 mg of sodium hyaluronate, or placebo. Facial hydration measurements favored both doses; forearm measurements did not show a consistent benefit. Self-rated hydration did not distinguish the treatment groups from placebo. The ingredient was specified at 1.8 million Daltons.3
These findings concern studied ingredients and preparations. Six authors of the later trial were employees of its ingredient manufacturer. Neither study establishes Multi+’s finished-product effect or a guaranteed result or timeline. The later trial also was not designed to establish benefits specifically in people taking GLP-1 medications.2,3
What is in WrenLife Multi+?
Each two-tablet serving is labeled to provide 120 mg of hyaluronic acid as sodium hyaluronate. Several trials used 120 mg daily, but matching the amount alone does not establish equivalent results.2,3
Hyaluronic acid form: Sodium hyaluronate
Labeled amount: 120 mg per serving
Serving size: Two tablets
Supplier-specified molecular weight: 1.2–1.5 million Daltons (1,200–1,500 kDa)
You can review the complete ingredient list and Supplement Facts on the Multi+ product page.
What does molecular weight tell us?
Molecular weight describes the mass of HA’s molecular chains. The supplier’s raw-material specification lists 1.2–1.5 million Daltons, a high-molecular-weight range. This is a supplier specification, not a measurement of each finished bottle.
The later trial used a different ingredient in liquid form at 1.8 million Daltons, outside that range. Its findings provide context, not proof of identical performance by Multi+ tablets. A molecular-weight specification alone does not establish absorption, clinical effectiveness, or superiority.3
Keep the rest of your skin routine in view
An oral supplement is one possible addition to a broader routine. Everyday skin care still matters. The American Academy of Dermatology recommends gentle cleansing, short showers with warm water, and a fragrance-free moisturizer applied after bathing. Persistent dryness, cracking, or irritation deserves advice from a dermatologist.4
Multi+ is a daily multivitamin. You do not have to take a GLP-1 medication to consider it, and it is not a treatment for medication side effects. It does not replace a varied diet or individualized medical care.
Follow the label directions and ask your healthcare professional whether Multi+ fits your routine, particularly if you take medications or other supplements. Multi+ contains 3,000 mcg of biotin per serving. Biotin can interfere with certain laboratory tests, so tell your healthcare professional and laboratory team that you take it before testing.5
Explore WrenLife GLP-1 Support Multi+ and view the Supplement Facts.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Sources
- Kawada C, et al. Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study. Journal of Clinical Biochemistry and Nutrition. 2015;56(1):66–73. doi:10.3164/jcbn.14-81.
- Sun Q, et al. Effectiveness of Dietary Supplement for Skin Moisturizing in Healthy Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in Nutrition. 2022;9:895192. doi:10.3389/fnut.2022.895192.
- Dolečková I, et al. Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults. Scientific Reports. 2026;16:2941. Published online December 20, 2025. doi:10.1038/s41598-025-32758-5.
- American Academy of Dermatology. Dermatologists’ tips for relieving dry skin.
- U.S. Food and Drug Administration. Biotin interference with laboratory tests.
